Your Textbooks Are Wrong, This Is What Cells Actually Look Like

I still remember the moment. That’s something
that I will never forget. The hair on my hands just stood up. It’s a microscopic universe
within each cell. This is an unprecedented view of the cellular world, where we can actually
see immune cells scooping up sugars in the ear of a zebrafish in real time. Focusing
only on the crawling immune cells, we’ve noticed two classes of them. One, it seems was not
hungry at all, but it was very active in terms of trying to figure out what the environment
is. But there was another one that was slouching around with a lot of food in its belly. We
can actually conceptualize, visualize, and analyze the contents of each of these cellular
compartments in this crawling immune cell as it’s scooping up its environment. That
is a level of detail no one’s ever seen before. We’re living in a new era of cell
biology, where microscopy advancements are giving biologists the opportunity to reveal
the hidden patterns of cells. What we expect to learn from here on out will transform our
understanding of human health and rewrite the textbooks on the fundamental unit of life. For centuries, microscopes have illuminated previously invisible worlds. We’ve learned
how cells divide and even discovered the existence of bacteria and microorganisms. These historical
breakthroughs are often found in your typical high school textbook. I fell in love with
the cell and wanting to understand the cell when I saw textbook images. I learned as I
started studying the cell, that those are vast simplifications of what those structures
actually do and what’s inside the cell. They don’t allow us to embrace the messiness and
complexity in the cell. At research organizations like the Allen Institute for Cell Science, biologists
are taking a more integrated view to better understand this complexity. So we at the
Institute are trying to think of all the structures of the cells in a holistic manner. If we don’t
understand which parts of the cell interact with which other ones we won’t ever be able
to understand the true mode of action of a drug, or perhaps where the side effects come
from. It’s that integrated knowledge of how when you pull here, you move there, that allows
us to understand the cell or the tissue or the organism properly. And if you don’t do
that you’re going to miss really important things. In order to see the patterns that
are actually happening in the cell in space and time, we have to be able to image the
cell well in space and time. New microscopy is what’s allowing us to image a cell in three
dimensions, in their native context without killing and hurting the cells, which is just absolutely needed for us to just study the cell as it is. But
seeing biological processes inside living samples without harming them is easier said
than done. One of the ways scientists image these dynamics is with fluorescence microscopy.
However, harsh light from this technique can cause phototoxicity, meaning the cell can
get sick during the imaging session. Lattice light-sheet microscopy was invented a few
years ago to correct for that challenge. So it’s a non-diffracting beam, meaning that
as the beam is traversing through the sample, it’s not converging or diverging. We put
several of these at very specific positions such that you interfere every beam with itself
and then create a very thin sheet of light. This fine sheet of light repeatedly sweeps
over a sample in order to avoid the damage that’s typically associated with other microscopy
techniques. The result builds a high resolution 3D movie depicting relatively undisturbed
living cells functioning over time. But tissues and other biological structures surrounding
cells tend to scramble the light from the microscope, resulting in blurriness. To compensate
for this, the same team behind the lattice light-sheet microscope borrowed a trick astronomers
use to get clear views of distant stars – adaptive optics. Just like how astronomers use lasers
as “guide stars” to course correct blurriness in telescopes, the process for looking at
the infinitesimally small world of cells through thick tissues and in living samples works
in the same way. Using a laser guide, aberrations that distort the light’s path are revealed
and corrected by the microscope. There’s several examples where we’ve worked with some
of the biologists, and showed them a few of our samples. Their reactions have typically
been, “Even though I’ve been studying this for a decade, it’s as if I’m looking at this
for the first time.” And that is always inspiring. Even just talking about this is giving me
goosebumps. With such promising feedback from biologists, Gokul and his
team of instrumentation scientists and computational experts are taking that technology one step
further in a newly created imaging center in Berkeley. This is unlike any microscope
you may have seen in high school. Its purpose is to shed light on molecular mechanisms that
are either poorly understood or not understood at all. MOSAIC is the Swiss army knife microscope,
as we have called it during development. And the reason we’ve called it the Swiss army
knife is because when we were trying to miniaturize the adaptive optics with lattice light sheet,
we realized that all of the components that go into building that microscope can be repurposed
to build a completely different microscope. MOSAIC combines about seven to 10 different
imaging modalities into one microscope. You can reconfigure or transform the microscope
from one mode into another mode. Such that you can interrogate your sample using different modalities. We’ve imaged everything from live
imaging, also everything that’s dead as well. Cells didn’t evolve in isolation. Cells didn’t
evolve on a cover slip. The goal of this whole project was to see, hey, can we create a tool
that will allow biologists to be able to look at their particular processes in a more physiological,
more natural environment. For you to have an effect in medicine and other fields, you need to understand to be able to perturb, mitigate and or intervene, right?  And that’s
basically what this is doing. This instrument is going to be laying the groundwork in order to help understand how a virus enters a cell. For instance, if
you can understand the mechanism by which it’s
fusing to the plasma membrane and then injecting its contents into the cell, you now have the
ability to intervene. The team behind MOSAIC has already built one instrument, and is in
the process of bringing a second one online. The next step will be opening up the instrument
to biologists. Because the thing is we can only get so far by ourselves. The goal is
to make sure folks that have the ability to have the impact, we want to make sure we break
the barriers down. Whether it’s access to instrument time, whether it’s access to computational
resources or working with the computational biologists. With tools like these soon coming
online, biologists like Susanne are excited about the next decade of cell biology. We
basically have a little alien world that none of us can wrap our minds around, and it’s
all of these technologies that are allowing us to start to do that more intuitively. Imagine
a world where you could look at a cell and you know what it’s doing, what it has done
and what it will do. That means that you could collect a pathological specimen, and without
too much perturbation or staining collect a whole bunch of information and features
just from the image, that let a pathologist know something about the prognosis of the
disease and the mechanism of why that’s the case. There will of course be more and more
innovation. That’s always how it works, but this set of innovation is going to get translated
into useful results for everyone. There’s literally trillions of inanimate molecules
inside of cells that work together somehow to create life. That’s basically what thousands
of scientists around the world are trying to understand is how life works. We want
to watch the dynamics, the interplay between these molecules in order to really understand
the complexity, understand the beauty of what is happening within the cells. Biology is
probably one of the last human forefronts. It’s the age of exploration again, but instead
of looking out at the galaxies, we’re looking at the galaxies inside of the cells.

100 thoughts on “Your Textbooks Are Wrong, This Is What Cells Actually Look Like

  • Hi Seekers, thanks for watching! Want more on the ever-changing world of microscopy? Check out this Elements on the world's first MRI of a single atom:

  • Maren says with her beautiful voice that systems like this will be coming online, the WebGl open source directibly in the bowser with creo costs of logistins, so as someone can feel with the sences the understanding of deep biology, for education

  • These retarded bastards can see all this, yet tell people they do not know what cancer is>? A bunch of lying bastards.

  • Anything worth knowing will be suppressed by those in control. Rockefeller’s Dept of Education intends to dumb down society, not educate it. “I want a nation of workers not a nation of thinkers” Rockefeller, 1913, founder of the Department of education.

  • I am not against knowledge. I am all for it, however I recognize its dangers as well. The better we get at manipulating our world, the more powerful we become. It makes me think of the story of the Garden of Eden, whether you are a believer or not, this story does make a lot of sense. God did not want humans to eat from the Tree of Knowledge, probably because with our sinful natures just think of the damage we would incur. As time goes by, we get closer and closer to having Godlike powers, yet we are not God, we are humans, so our knowledge must always be checked with restraint and common sense. The problem again is that we are humankind, not God, so this does not always happen. This is why humankind is a scary, very scary, holder of the key of knowledge.

  • ROYAL RIFE had something similar in the 20s, his technology was BURIED for AMA profit! Our medical system is a fraud to keep ppl sick!!

  • THANX one more time, keep informing the positive good things that hapens in our universe.
    Related to what I comented of the TZOLKIN MAYAN CALENDER that conects to THE FLOWER OF LIFE OR DNA DECODED video in you tube that conects me here in this place to comment that is needed to understand that they are a complement one to the other so lets get in the subject in colors that is needed to understand the levels of light all over space, next to come are some densetys by the rainbow colors that are 7 but we will begen with the 8TH color that is black and stands for GROUND or as i say is planetary it contains the 8 in the disk including it self then we will begen from top that is red to go down as the rainbow to the bottom sea of colors that is white this in one tzolkin tablet then we will form the SERNAS HOLOGRAM by uniting 6 of this tablets:

    BLACK= 84 Hz. represents planet NEPTUNE.
    RED = 420 HZ URANUS.
    GREEN = 252 MARS.
    BLUE 196 EARTH.

    The Sernas Hologram is obteind by multyplying each color by 6 so lets doit
    BLACK 504 Hz NEPTUN.
    RED 2520 URANUS.
    GREEN 1512 MARS.
    BLUE 1176 EARTH.

    10920 is what we get by adding all the above numbers, its HIGH FACE.
    10416 is by not counting BLACK, its MEDLE FACE.
    10080 is by not counting BLACK AND WHITE, ITS LOW FACE.
    31416 results if we add the 3 of above that are the 3 FACES with the ones the unierse works.
    31416 is a common number in any form you look at it. To find COMMON DENOMINATORS is very common in all numbers so get use to the UPS or DOWNS so the small and the big here is no problem they fit well some just perfect in some known numbers and some not to common ones and maybe some not known.

    Lets do some exersize and see that colors or planets are entangled by pairs:if we add:
    RED that is 2520Hz and VIOLET that is 840 we get 3360 Hz.
    ORANGE 2184 pluss 1176 that is BLUE = 3360.
    YELLOW 1848 pluss 1512 that is MARS = 3360.
    In this case we dont count BLACK cause is ground so white stays with 336, notice that all the pairs of above are in all cases 10 times higher than white and this is why we dont need of DARK MATTER sinse in all pairs it is 10 times more than white a thing we need for our universe to make balance in it same as it is out there.

    Some times I will count all of the factors or groups as say the gravity of the 8 in the disc all added that is
    77.86 m/s 2 is like say if one cell weights 3 grams how much does our body all togather as a group.
    77.86 is found 7 times in a TZOLKIN and 42 in a Sernas Hologram also 42 are the petals of a flower of life or the DNA figure in you tube. 42 fits inso many forms making good numbers coming later.
    351.86 comes from the gravity of all of the 8 planets in the disk pluss 274 that is the solar gravity.
    3.1416/351.86 = 112.00025.
    112.00025/300000K/S that is light speed in everage in yellow side = 2678.5654/89.28 = 30.001852.
    89.28 is the result of 351.86/31416 practicly.
    149.6 millions of Km.for suns light to reach erth times 210 = 31416 in the way you will notice that 21 or common denominators of it from all arround same of 20 and 22 where 21 is at the meadle is like a center or ecuator as many other numbers from all sourses.
    10920/3141600 = 287.6923/144 = 1.9978631.
    10416/3141600 = 301.6129/3.1416 = 96.006143.
    17126.594 is the mass of all the 118 places of the periodic table/96.006143 = 178.39936/89.28 =1.9982007.
    10080/3141600 = 311.66660/77.86 = 4.002911.

    22 Earth years is a complite suns cicle based in black spots in the sun.
    22 X 365.25 = 8035.5/10920000 = 1358.9695/3.1416 = 432.57241/144 = 3.003975.
    8035.5/161800 = 20.135648/3.1416 =6.4093608 – 6.472(1.618 x 4) = 0.0626392.

    144 is a number of the SERIE PHI. and is a common denominator of 1440 that are the minutes of a day practicly.
    22/10920 = 496.36363/3.1416 = 157.99708/17126.594 = 108.39816/1.618 = 66.995154.
    77.86/157.99708 = 2.0292458.
    22/31416 = 1428/300000 = 210.08403.
    1428/17126.594 = 11.993413.
    22/17126.594 = 778.48154/77.86 = 9.9984785.
    22/16180 that is the golden ratio 10000 times = 735.45454/3141600 = 4271.644/3.1416 = 1359.7033/3.1416 = 432.80599/144 = 3.0058971
    432 is a common denominator of 432KHz that are the ones of our sun.
    1359.7033/17126.594 = 125.95831/1.618 = 77.848152 – 77.86 = 0.011848.

    42 are the petal of the flower of life:
    42/10920 = 260/300000 = 1153.8461/3.1416 = 367.27976/1.618 = 226.99614/17126.594 = 75.448833/3.1416 = 24.01605 that is near to 24 that are the hours of a day:
    24/17126.594 = 713.60809/89.28 = 7.992922.
    24/10920 = 455.
    24/10416 = 434.
    24/10080 = 420 that is comon denominator of 42.
    24/31416 = 1309.
    24/300000 = 12500.
    42/300000 = 7142.8571/314160 = 43.9824/3.1416 = 14.
    43.9824/17126.594 = 389.39653/77.86 = 5.0012397.
    42/10416 = 248.
    42/31416 =748.
    42/17126.594 = 407.77604/300000 = 735.69795 same as 22/16180 = 735.45454.

    11.2K/S Is the earth scape velocity:
    11.2/300000 = 26785.714/89.28 = 300.01908.
    11.2/31416 = 2805/3.1416 = 892.85714/89.28 = 10.00064.
    11.2/351.86 = 31.416071/3.1416 = 10.000022.
    11.2/10920 = 975.

    618KM/S is the suns scape velocity:
    618/16180 = 26.181229/1.618 =16.181229/31416 = 1941.5088/3.1416 = 618.

    There are much more numbers for thousands of this some way or the other that cant be just pure coinsidense.

  • The Lord Jesus Christ showed off creating the biology of the human body. He is Alpha & Omega, The Beginning and The End, The Son of God, Savior of Humanity, and The Only Way to Eternal Life in Heaven with God The Father.

  • Awesome, but I don't think there's enough detail and that's not what cells "look like". My text book never said what the insides looked like. So kind of misleading.

  • I see many saying text books lied. But it's not clear what they lied about. If it's the cell, then maybe they lied aboutvthe technology used to see a cell. I've seen many cells under a microscope and they looked like those in my text books. Though I never asked if there was better tecjnology to ser the cell.

  • I hypothesize that light is the underlying source which provides what we call life to the inanimate material within cells

  • What I cant figure out is why there are 514 dislikes! 514 myopic back woods knuckle-draggers? We live in the era of fake news, the hate of intellect, and all out assault on logic and reason.

  • All Life is Bio-Electromagnetic, without it we would be machines with NO SOUL. Now look in to the world that ICNIRP refuses to acknowledge it's significance in relation to nnEMFS (Non Native EMF Disruption/ #5G Distortion/Erratic Interference): … #Stop5G … Research

  • In the future when you go see your GP they'll be wearing welding goggles and gloves. "Come lets see what's going on in that head of yours."

  • @Seeker this videos doesnt make our textbook WRONG! It doesn't mean that if you just can't see more clearer images makes it WRONG! maybe on your perspective, just to clickbait some people, many children watch your videos and they might take a WRONG idea beacuse of your title! use your titles more wisely, my son keeps arguing with me that he doesn't like books because of so many stupid titles that just makes it more interesting to them!

  • Wow. Micro universe.
    I wonder if they started with a big bang too. Umm only God know's.
    Oh wait. That's only if there is a God. Lol.

  • If they can know completely how virus affects through this ultra microscopic videos , then hopefully in next 15 to 20 years all the deadly virus diseases will have cure . Life expectancy will take a big leap.
    Most of the cancers will be prevented , diagnosed very early and treated with ultra- precision.

  • If inanimate objects are things that don't move on their own, and animate things are made of matter going through sustained constant chemical reactions, maybe that's just it. Maybe there is no big secret and life as we know it just comes from the way atoms and molecules naturally want to interact and the real secret is how to create an ongoing chemical reaction that can sustain itself?

  • Adaptivd Optics should be ITAR. Dept. of Commerce needs to protect this technology from "bad people" and "enemies"

  • Why does seeker videos come on my feed if I Am not subscribed? If I subscribe will you stop coming on my feed like all other subscriptions have?

  • Watching this at midnight, thinking how this is happening in me right now, so creepy, amazing. Also I just took an antibiotic. There's a war going on inside of me.

  • The title is too harsh, former biologists didn't have the luck of getting such an advanced technology to look into the small things that make our world. It's aredy an achievement that they got to give us an aproximate view of it.

  • WELL UM BOOKS ARE 2D POINTDEXTER!!!!! YIKES MAN its like that old Gary LARSON comic where a student cant get into his GIFTED SMART SCHOOL because he doesn't even know how to pull the door, this videos is like that. When you become so smart you are stupid as rocks

  • Now imagine the instability created in that cell when the cell is next to radio and cellular waves.
    More fire on that flame sir?
    We got the money for it.
    These asshole remark's are redeveloped driver's for your brain.
    Intended to drive.
    Intended to be cold.
    Out of warmth and love.
    Choke on it.

  • Looking at some of those images looks like the images of the universe, maybe our universe is just one cell of a much larger being 😉

  • You mean [a cell is] the fundamental unit of TERRESTRIAL life. We don't know what life is like out there in the Universe. We can't even get to agree on a general definition of life. What is life (in its most general form)? That's the question!

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